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Symbol Name ID |
Pcsk2
proprotein convertase subtilisin/kexin type 2 MGI:97512 |
| Darker colors indicate more annotations |
| Human Phenotypes | Type II diabetes mellitus |
| Disease(s) Associated with PCSK2 | |
| type 2 diabetes mellitus |
| Mouse Phenotypes | abnormal pancreatic alpha cell differentiation |
abnormal pancreatic beta cell differentiation |
increased pancreatic alpha cell proliferation |
abnormal pancreatic islet morphology |
abnormal pancreatic alpha cell morphology |
increased pancreatic alpha cell mass |
increased pancreatic alpha cell number |
decreased pancreatic beta cell number |
increased pancreatic delta cell number |
enlarged pancreatic islets |
pancreatic islet hyperplasia |
increased pancreas tumor incidence |
increased pancreatic islet cell adenoma incidence |
increased glucagonoma incidence |
increased pancreatic ductal adenocarcinoma incidence |
abnormal gland physiology |
decreased glucagon secretion |
decreased insulin secretion |
abnormal pancreatic somatostatin secretion |
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| Availability | Mouse Genotype | |||||||||||||||||||
| Pcsk2tm1Dfs/Pcsk2tm1Dfs | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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